Exosomes

What Are Exosomes?

Exosomes are tiny lipid vesicles that are secreted by many cell types. They contain proteins, growth factors, and growth factor messenger RNA required for intercellular communication, and ultimately, cell growth. Exosomes form by the inward budding of cellular compartments known as multivesicular endosomes (mVE). When mVE fuse with the plasma membrane, exosomes are released, and can travel to distant tissues to influence various aspects of cell behavior and physiology.

How Do Exosomes Work?

Of their many essential functions, exosomes home to injury, providing regenerative properties and the anti-inflammatory response necessary to create new tissue. As we age, there is a gradual decline in the regenerative potential of our cells, particularly exosomes. Research shows exosome therapy—the process of delivering mesenchymal stem cell (MSC)-derived exosomes to targeted areas of the body—holds immense potential to influence a person’s overall health and wellness.

If your provider determines you are an optimal candidate for exosome therapy, certain testing may be performed to evaluate your overall health. The treatment itself takes under 30 minutes and can be done in the comfort of your provider’s office. Depending on the area your provider is targeting, exosomes may be delivered topically, intrathecally, intravenously, intranasally, or via injection.

Exosomes Frequently Asked Questions:

Yes! Our practice uses exosomes from an FDA-registered tissue laboratory that delivers purified placental MSC-derived exosomes. The actual cells are removed from the product, leaving a powerful combination of regenerative proteins and nucleic acids that are not perceived as foreign by the body. All exosomes are tested to ensure sterility and overall safety.

Placental MSC exosomes release over 300 growth factors. In comparison, the average 40-year-old adult releases 100—and that number continues to decrease with age. The exosomes we use are specifically designed to contain the growth factors that instruct a child’s cells to grow. When these messages communicate with your cells, they re-instruct your cells to behave like a child’s reaction.

Exosome therapy may actually stop the pain associated with your treatment by rapidly suppressing inflammation and alleviating the ‘burning’ sensation often experienced with similar therapies.
Exosomes are often, but not always, combined with PRP (platelet-rich plasma) in a treatment regimen. This depends on the area and symptoms desired for treatment. Your provider will discuss if PRP is needed at time of consult.